Metabolomics for the masses: The future of metabolomics in a personalized world
نویسندگان
چکیده
Current clinical practices focus on a small number of biochemical directly related to the pathophysiology with patients and thus only describe a very limited metabolome of a patient and fail to consider the interations of these small molecules. This lack of extended information may prevent clinicians from making the best possible therapeutic interventions in sufficient time to improve patient care. Various post-genomics '('omic)' approaches have been used for therapeutic interventions previously. Metabolomics now a well-established'omics approach, has been widely adopted as a novel approach for biomarker discovery and in tandem with genomics (especially SNPs and GWAS) has the potential for providing systemic understanding of the underlying causes of pathology. In this review, we discuss the relevance of metabolomics approaches in clinical sciences and its potential for biomarker discovery which may help guide clinical interventions. Although a powerful and potentially high throughput approach for biomarker discovery at the molecular level, true translation of metabolomics into clinics is an extremely slow process. Quicker adaptation of biomarkers discovered using metabolomics can be possible with novel portable and wearable technologies aided by clever data mining, as well as deep learning and artificial intelligence; we shall also discuss this with an eye to the future of precision medicine where metabolomics can be delivered to the masses.
منابع مشابه
Evaluation of the Anticancer Effect of Xanthium Strumarium Root Extract on Human Epithelial Ovarian Cancer Cells Using 1H NMR-Based Metabolomics
Epithelial Ovarian cancer is the leading cause of cancer mortality among women all over the world. As chemotherapeutics has many side effects, researchers have focused on the potential use of medicinal plants as natural antitumor agents. Xanthium strumarium studied in this work as an herbal anticancer agent. This study aimed to evaluate the antitumor effect and metabolic alterations ca...
متن کاملمتابولومیکس، چشماندازی برای مردان نابارور: مقاله مروری
Infertility influences an estimated 20% of couples worldwide. The factors that can affect the fertility potential are equally distributed between men and women. Despite extensive research in male infertility, the etiology in majority of infertile men is unknown. In 2010, there was an opinion published in Nature asking a selection of leading researchers and policy-makers about what their future ...
متن کاملEffects of Clinacanthus nutans leaf extract on lipopolysaccharide -induced neuroinflammation in rats: A behavioral and 1H NMR-based metabolomics study
Objective: This research revealed the biochemical outcomes of metabolic dysregulation in serum associated with physiological sickness behavior following lipopolysaccharide (LPS)-induced neuroinflammation in rats, and treatment with Clinacanthus nutans (CN). Verification of 1H NMR analysis of the CN aqueous extract proved the existence of bioactive phytochemical constituents’ in extract. Materia...
متن کاملMetabolomics Application in Exercise Metabolism Research: A Review Study
Metabolomics, is a comprehensive measure of small metabolites (<1500 Da), which has attracted enormous attention in the last two decades. Metabolomics, in particular investigates unique biochemical fingerprints left behind by specific cellular processes, which represent the metabolic status. Exercise metabolism researchers have started to use this method since 2007. Metabolomics has been used t...
متن کاملClassification of Chronic Kidney Disease Patients via k-important Neighbors in High Dimensional Metabolomics Dataset
Background: Chronic kidney disease (CKD), characterized by progressive loss of renal function, is becoming a growing problem in the general population. New analytical technologies such as “omics”-based approaches, including metabolomics, provide a useful platform for biomarker discovery and improvement of CKD management. In metabolomics studies, not only prediction accuracy is ...
متن کامل